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Extending The Life Of An Appetite-Suppressing Peptide
The peptide alpha-MSH works in a region of the brain known as the hypothalamus to suppress appetite. A team of researchers, at Yale University School of Medicine, New Haven, and the University of California Davis, has provided new insight into the way in which levels of the active form of alpha-MSH are regulated in mice. Specifically, genetic and biochemical analysis performed by the team, led by Sabrina Diano and Craig Warden, indicated that the protein PRCP is expressed in the hypothalamus and breaks down the active form of alpha-MSH, generating a slightly smaller peptide that does not suppress food intake. Importantly, administration of PRCP inhibitors to both normal and obese mice reduced their food intake. Further, mice lacking PRCP had increased levels of the active form of alpha-MSH in the hypothalamus and were leaner and shorter than normal mice; they also did not get obese when fed a high-fat diet. The authors suggest that these data are the first step in identifying PRCP as a candidate drug target for the treatment of obesity and obesity-related disorders. Although Richard Palmiter, at the University of Washington, Seattle, also raises this intriguing possibility, he cautions that any drug would need to penetrate the brain. Don't forget to buy zoloft online no prescription.

Rise In Computer-Related Injuries
While back pain, blurred vision and mouse-related injuries are now well-documented hazards of long-term computer use, the number of acute injuries connected to computers is rising rapidly. According to a study published in the July 2009 issue of the American Journal of Preventive Medicine, researchers from the Center for Injury Research and Policy and The Research Institute at Nationwide Children"s Hospital; and The Ohio State University College of Medicine, Columbus have found a more-than-sevenfold increase in computer-related injuries due to tripping over computer equipment, head injuries due to computer monitor falls and other physical incidents.

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FDA Approves Expanded Use Of HIV Drug
Merck announced on Thursday that the FDA has approved expanded use of its HIV drug, Isentress, Reuters reports (Pierson, 7/9). Isentress has been FDA-approved since 2007, but was limited "to use in patients who had drug-resistant strains or were failing on other therapies, also in combination with other HIV drugs. Now it can be used in all adult patients," the AP/CNBC.com reports. According to AP/CNBC.com, "Isentress is an integrase inhibitor, meaning it works by blocking the enzyme integrase, one of three types of enzymes the AIDS virus uses to reproduce and infect cells" (7/9).
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Wall Street Journal Examines Group Health Insurance Policies As Option For Uninsured

People who no longer have health insurance because of a job loss, voluntary retirement or other reasons have begun obtaining health coverage through the "little-known" option of group coverage, the Wall Street Journal reports. According to the Journal, the option is especially beneficial for people with pre-existing conditions to whom some insurers deny coverage. Federal law requires group policies to cover pre-existing conditions provided a person has not been uninsured for more than 63 days.To qualify for group coverage, an individual, a couple or a small group of people must provide evidence of ownership of an actual business, which could include freelance, contract or consulting work. Industry experts note that rules vary between states. In addition, group coverage could cost more than individual coverage, according to the Journal. The Journal reports that insurance companies might add extra fees for smaller groups. The smallest groups, sometimes of two or three people, can face surcharges of about 30% more than what larger groups pay, according to insurance broker Rick Martin.According to the Journal, it is unclear how many business owners currently are eligible for group coverage. Data from the Kaiser Family Foundation indicate that about one-third of the four million uninsured U.S. residents between ages 55 and 64 are self-employed, the Journal reports (Greene, Wall Street Journal, 5/27). Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation. © 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.


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