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In Trastuzumab-Resistant Metastatic Breast Cancer, Small Molecule Inhibitor Shows Promise
Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab based therapies. More than one-quarter of the women in a phase I/II trial had their tumors shrink on the combination therapy. Buy arimidex to treat cancer.

Teens Are Exposed To Tobacco Content On Social Networking Sites
When teens surf the Internet, are they exposed to tobacco content or imagery? The study, "Exposure to Tobacco on the Internet: Content Analysis of Adolescents" Internet Use," tracked the Web pages viewed by 346 teens between the ages of 14 and 17 years. During a one-month period of data collection, these adolescents viewed 1.2 million Web pages. Of those pages, 0.72 percent contained tobacco or smoking content. Pro-tobacco content was found on 1,916 pages, anti-tobacco content on 1,572 pages, and complex and/or unclear content on 5,055 pages. Most of the tobacco-related content seen by teens was found on social networking sites. MySpace in particular represented 53 percent of the pages on which tobacco content was found. Previous studies have found a link between exposure to tobacco content in traditional media and adolescent smoking. The authors caution that as more communication occurs online in social networking sites, this may also impact adolescent smoking.

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Report Finds Racial Health Disparities Among New York State Health Plan Beneficiaries
The New York City-based advocacy group Community Service Society recently released a report that found racial health disparities among state health plan beneficiaries, New York Times" "City Room" reports. The report urged state officials to close the gaps. The roughly 20 health plans that contract with the state public health programs to provide health insurance to low-income residents are required to break down health indicators by race. Using data from the New York State Department of Health, researchers found that out of 12 measures the state uses in quality assurance, including dental visits, asthma management, mammography and almost all diabetes indicators:
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Risk Factors For Cardiovascular Disease Increasing In Younger Canadians Raise Concern About Future Rise In Heart Disease

The prevalence of heart disease and certain key risk factors - hypertension, diabetes, and obesity - are increasing in all age groups and most income groups in Canada found a new study published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/press/cmaj081629.pdf. This study, which looked at national data from 1994 to 2005, encompassed people aged 12 years and older sampling from Canadians of all socioeconomic and ethnic groups. Risk factors such as hypertension, diabetes, and obesity increased most rapidly among younger people between 12 to 50 years of age. The increasing prevalence of heart disease in Canada is likely related to both earlier detection and better survival among those with cardiovascular disease. More Canadians are surviving their first heart attack. The prevalence of heart disease is rising fastest among Canadians of lower socioeconomic status, who also tend to have the highest cardiovascular risk profiles. This increase in risk factors in younger Canadians has significant health implications because it predisposes people to earlier onset heart disease. It can place greater burden on health care res as younger people may need longer, and perhaps more intense, treatment. The study found an estimated 1.29 million Canadians reported having heart disease in 2005, a 19.3% increase in men and 2.1% increase in women compared with 1994. Although people who were of lower socioeconomic status had the highest risk factor burden, hypertension prevalence nearly doubled and obesity increased over time in all socioeconomic groups. Diabetes is also increasing in almost all income groups, although the gap between the richest and the poorest is widening over time. The authors found that hypertension and diabetes are increasing most in those who were obese or overweight. "Projections suggest that the rising prevalence of obesity in the current generation of adolescents will increase the prevalence of coronary heart disease by 5 to 16% in 2035, and may for the first time in 2 centuries significantly reduce life expectancy in the 21st century," state Dr. Douglas Lee of the Institute for Clinical Evaluative Sciences (ICES) and coauthors. "This study has implications for all Canadians because the surveys were conducted in a representative sample of the Canadian population, including all ethnic groups," write the authors. "Our findings draw attention to risk factors in early adulthood, which predict cardiovascular disease of early onset and are associated with greater need for health care res in the last years of life." Interventions to encourage healthy eating, exercise and provision of preventative medications such as smoking cessation therapy in at-risk groups may help reduce widening disparities between the highest and lowest socioeconomic groups. The study was conducted by researchers from the Institute for Clinical Evaluative Sciences, University Health Network, University of Toronto, Sunnybrook Health Sciences Centre, Toronto; Queen"s University, Kingston, Ontario; University of Alberta, University of Calgary, Alberta; Dalhousie University, Halifax, Nova Scotia; and Statistics Canada. It was funded by the Canadian Institutes of Health Research (CIHR). The declines in mortality associated with heart disease may be at an end, writes Dr. Annika Rosengren of Sahlgrenska Academy, Goteborg, Sweden in a related commentary http://www.cmaj.ca/press/cmaj090911.pdf. The decline in rates for young people in England, Wales and the US has begun to level off and may also be happening in Canada. She argues for action that focuses broadly on societal changes to fight obesity such as healthy eating and exercise. Canadian Medical Association Journal


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