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Extending The Life Of An Appetite-Suppressing Peptide
The peptide alpha-MSH works in a region of the brain known as the hypothalamus to suppress appetite. A team of researchers, at Yale University School of Medicine, New Haven, and the University of California Davis, has provided new insight into the way in which levels of the active form of alpha-MSH are regulated in mice. Specifically, genetic and biochemical analysis performed by the team, led by Sabrina Diano and Craig Warden, indicated that the protein PRCP is expressed in the hypothalamus and breaks down the active form of alpha-MSH, generating a slightly smaller peptide that does not suppress food intake. Importantly, administration of PRCP inhibitors to both normal and obese mice reduced their food intake. Further, mice lacking PRCP had increased levels of the active form of alpha-MSH in the hypothalamus and were leaner and shorter than normal mice; they also did not get obese when fed a high-fat diet. The authors suggest that these data are the first step in identifying PRCP as a candidate drug target for the treatment of obesity and obesity-related disorders. Although Richard Palmiter, at the University of Washington, Seattle, also raises this intriguing possibility, he cautions that any drug would need to penetrate the brain. Don't forget to buy zoloft online no prescription.

PolyMedix Receives Regulatory Clearance To Initiate Second Phase I Clinical Study Of Novel Systemic Antibiotic Compound
PolyMedix, Inc., an emerging biotechnology company developing acute care products for infectious diseases and acute cardiovascular disorders, has received a notice of no objection from Health Canada for the Company"s Clinical Trial Application ("CTA") for its defensin mimetic antibiotic compound, PMX-30063. This notice of no objection allows for the initiation of the second human clinical study in Canada. PMX-30063 is a defensin mimetic antibiotic compound, the first of an entirely new class of antibiotic drugs that is believed to work in such a way that makes bacterial resistance unlikely to develop.

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Opinion: Boston Globe Columnist Examines Arguments Against DDT Use In Uganda
Boston Globe columnist Derrick Jackson examines why some Ugandans do not support indoor spraying of DDT to prevent malaria. Grace Kagoro, a biology professor and environmental researcher at Mbarara University of Science and Technology, is "nervous about adding what she said could be one more shock to the soil and water," according to Jackson.
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Proportion Of Fatal Crashes Increases

An emergency rule intended to reduce the number of deaths and injuries associated with Hawaiian air tours was followed by a 47 percent reduction in sightseeing crashes, according to a new study by researchers from the Johns Hopkins Bloomberg School of Public Health"s Center for Injury Research and Policy. However, the proportion of crashes that resulted in lives lost actually increased after the rule change due to an increase in crashes that resulted from poor visibility, which tend to be exceptionally fatal. The report is published in the July issue of Aviation, Space, and Environmental Medicine. The Federal Aviation Administration (FAA) issued Special Federal Aviation Regulation (SFAR) 71 in 1994 in response to a spate of crashes of helicopter sightseeing tours that year. The regulation established minimum flight altitudes and clearances from terrain, emphasized passenger safety precautions, mandated performance plans prior to each flight, and required flotation equipment or the wearing of life preservers on flights beyond the shoreline. "Our findings indicate that the 1994 Rule was followed by a reduction of almost half in the crash rate. On the other hand, crashes that occurred as a result of low visibility-often because of rain, fog, or clouds-increased from 5 percent to 32 percent of all air tour helicopter crashes in the 14 years after the new regulation," said senior author Wren L. Haaland, a 2009 graduate of Johns Hopkins University who conducted the study as an undergraduate research assistant with the Bloomberg School"s Center for Injury Research and Policy. "Our data suggest the FAA should reconsider the Rule"s clause that established a minimum flying altitude of 1,500 feet, as we know higher altitudes are associated with more cloud cover," said Susan P. Baker, MPH, director of the study"s research and professor with the Injury Center. Clouds obscuring mountain peaks and passes are particularly common in Hawaii. The Hawaii Helicopter Operators Association appealed the Rule on the basis that the 1,500-feet above-ground-level minimum flying altitude would lead to crashes due to the prevalence of clouds at or above that altitude. The appeal was rejected by the U.S. Ninth Circuit Court of Appeals. The researcher team analyzed data collected from the National Transportation Safety Board"s Aviation Accident Database, identifying 59 crashes of helicopter air tour flights in Hawaii from 1981 through 2008. Crashes in 1995 to 2008 were compared with those in 1981 to 1994. The greatest decreases occurred in crashes into the ocean, crashes not involving malfunctions, and nonfatal crashes. Aircraft malfunctions were the most common precipitating factor throughout the study period, occurring at similar frequencies pre- and post- regulations. The most common malfunction was loss of power, most often caused by improper maintenance. Forty-six tourists and 9 pilots died in 16 fatal crashes during the 28-year study period. "The persistence of mechanical problems and malfunctions is noteworthy, since they were related to the majority of crashes and not addressed by the FAA"s 1994 Rule," said Dennis F. Shanahan, MD, MPH, a co-author of the study. "This is an oversight, as many of these problems could be prevented through better mechanic training, closer FAA oversight, and increased emphasis from management on proper and thorough maintenance procedures. Helicopter tourism is popular in other areas such as Alaska and the Grand Canyon, and every precaution should be taken to save lives." The research was funded by grants from the Centers for Disease Control and Prevention to the Johns Hopkins Center for Injury Research and Policy. Tim Parsons Johns Hopkins University Bloomberg School of Public Health


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