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Individuals Genetically At Risk Of Developing Psychological Disorders Also Benefit The Most From Positive Environments
Certain individuals have long been regarded as particularly susceptible to developing behavioural and emotional problems when they experience negative environmental conditions, due to the fact that they carry so-called "vulnerability genes". Existing research suggests, for instance, that such "genetically vulnerable" individuals are most likely to become impulsive and hyperactive if their mothers smoked while pregnant, to behave anti-socially if subjected to child abuse, and to become depressed if exposed to many negative life events (e.g., divorce, unemployment). But a new evaluation of existing gene-by-environment interaction (GXE) research highlighting such genetic vulnerability to adversity challenges this traditional interpretation of existing evidence. Research published in Molecular Psychiatry suggests that those carrying "vulnerability genes" are not only more likely than others to be adversely affected by negative experiences but to also benefit more than others from positive environments, making them more malleable or plastic, not just vulnerable. This novel interpretation of old and new findings suggests that "vulnerability genes" might be better conceptualised as "plasticity or malleability genes" because carriers are more affected, for better and for worse, by positive and negative environmental conditions. Don't forget to buy zoloft online no prescription.

Diabetes Wounds Healed With Oxygen Under Pressure
Every 30 seconds a person somewhere in the world loses a lower limb to amputation due to diabetic foot disease.

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Largest Lung Cancer Study, MAGRIT, Shows Collective Commitment To Development Of Tailored Cancer Therapy
Data presented on Sunday at the The International Society of Lung Cancer (IASLC) 13th World Conference on Lung Cancer (WCLC) in San Francisco highlight the screening of over 3,000 patients for MAGRIT (MAGE-A3 as Adjuvant Non-Small Cell LunG CanceR ImmunoTherapy)1, the largest-ever treatment trial in lung cancer. The rapid screening of patients into the MAGRIT trial is unprecedented given so few eligible lung cancer patients (less than 1% in the U.S.2) traditionally enter clinical trials and benefit from the potential hope of novel treatments.
Endocrinology

Novartis To Partner With OneWorld Health To Develop Diarrhea Drug

"Swiss drug company Novartis AG and the Institute for OneWorld Health, a nonprofit group, will announce this week a partnership to discover drugs for a type of diarrhea that kills about 1.6 million children each year in the developing world," the Wall Street Journal reports. Though fluid treatments to prevent dehydration have helped "sharply cut the number of deaths" from secretory diarrhea in recent years "additional treatments are desperately needed, Richard Chin, chief executive of OneWorld Health, said in a phone interview," the newspaper writes. As part of the partnership, ten Novartis scientists will first sift through drugs candidates, before "pass[ing] along any promising candidates to OneWorld Health for further testing." The newspaper writes: "OneWorld Health, based in San Francisco, has been working on secretory diarrhea since 2006, using a $47 million grant from the Bill and Melinda Gates Foundation. The group already has a research partnership with Swiss drug company Roche Holding AG, which has allowed the nonprofit group to scan Roche"s library of experimental drugs for candidates that might work against diarrhea" (Whalen, 7/14). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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