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Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity
Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli. Don't forget to buy zoloft online no prescription.

Youth Baseball-Related Injuries Down 25 Percent, National Study Finds
Spring marks baseball season for more than 19 million children and adolescents who play each year as part of a team or in backyards throughout the United States. The good news for these players is that the number of injuries from the sport is on the decline. A new study by the Center for Injury Research and Policy of The Research Institute at Nationwide Children"s Hospital found that the number of children and adolescents treated for baseball-related injuries in hospital emergency departments decreased 25 percent from 1994 through 2006 - going from an estimated 147,000 injuries in 1994 to approximately 111,000 injuries in 2006. This is the first national study of youth baseball injuries requiring emergency treatment, and is now available online in the June electronic issue of Pediatrics.

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New Family-Focused Model Of Depression Care Needed To Minimize Risks And Problems For Parents With Depression And Their Children
Health and social service professionals who care for adults with depression should not only tackle their clients" physical and mental health, but also detect and prevent possible spillover effects on their children, says a new report from the National Research Council and Institute of Medicine. To achieve this new family-focused model of depression care, federal and state agencies, nonprofits, and the private sector will have to experiment with nontraditional ways of organizing, paying for, and delivering services, said the committee that wrote the report.
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New Laws Boost Immunization Practices

As a parent, you may know if your child"s shots are current. But what about yourself? Do you know when you had your last tetanus shot, or any other shots for that matter? A new Texas law will help adults better track their and their children"s vaccinations. Sen. Jane Nelson (R-Lewisville) pushed for legislation this session to track vaccinations throughout a person"s lifetime. She also advocated for new laws to help Texas respond to the immunization needs of its citizens during an emergency or disaster. "These new laws are important to keep Texans healthy and prevent the spread of serious and often deadly diseases," said Jeffrey L. Levin, MD, MSPH, chair of the Texas Medical Association (TMA) Council on Public Health. "The recent swine flu outbreak reminded us just how important vaccinations are for both children and adults," added the Tyler physician. Gov. Rick Perry already has signed both of these measures into law. Senate Bill 346 makes ImmTrac, Texas" free immunization registry, a lifespan registry. Now when a child becomes an adult, his or her vaccination records can be maintained in the state"s registry. Prior to this legislation, immunization records could only be kept for children up to age 18. SB 347 allows Texas to exchange vaccination information with other states during declared disasters. This is especially important when residents are relocated to other states in emergencies, such as when New Orleans residents came to Texas during Hurricane Katrina. Doctors say having access to each patient"s vaccination status saves time and is more cost-efficient, especially during an outbreak of a vaccine-preventable disease such as pertussis. Texas has seen pertussis outbreaks in some communities. Tracking vaccines also helps to ensure patients only get the shots they need. TMA physicians applaud the Texas Legislature for these steps to improve the health of Texas residents. "These advances in tracking vaccinations will help us take better care of Texans throughout their lives - and when disaster strikes," said Dr. Levin. These laws are a win-win for the people of Texas and for the physicians who treat them." TMA is actively involved in improving immunization practices in Texas through its Be Wise - ImmunizeSM program. The program works to educate physicians and the public about the latest vaccination practices. Since the program began in 2004, more than 127,000 vaccinations have been given to Texas children. TMA is the largest state medical society in the nation, representing nearly 44,000 physician and medical student members. It is located in Austin and has 120 component county medical societies around the state. TMA"s key objective since 1853 is to improve the health of all Texans. Texas Medical Association


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