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Anti-Thyroid Drug Linked To Serious Liver Injury Warns FDA
The US Food and Drug Administration (FDA) are warning health care professionals about the risk of serious liver injury linked to the anti-thyroid drug propylthiouracil that is used to treat Graves" disease, an autoimmune disorder that results in overactivity of the thyroid gland. Don't forget to buy zoloft online no prescription.

World Health Organization And International Atomic Energy Agency Join Forces To Fight Cancer
The World Health Organization (WHO) and the International Atomic Energy Agency (IAEA) today announced the launch of a Joint Programme on Cancer Control, aimed at strengthening and accelerating efforts to fight cancer in the developing world.

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Media Devotes Little Attention To Sotomayor's Catholicism Compared With Conservative Nominees, WSJ Columnist Writes
Supreme Court nominee Sonia Sotomayor would be the sixth Roman Catholic currently on the court if she is confirmed, but there have been no more than "a few scattered references to this fact," Wall Street Journal columnist William McGurn writes. He continues that "for the most part the judge"s religion has been greeted, as a USA Today headline put it, with a "yawn."" McGurn adds, "How different from just a few years ago," when Catholics Justice Samuel Alito and Chief Justice John Roberts were nominated by former President George W. Bush.According to McGurn, when Alito was a Supreme Court nominee, "talk was about the "fifth Catholic" on the bench." He adds that Feminist Majority Foundation President Eleanor Smeal "complained that "with Alito, the majority of the court would be Roman Catholics."" McGurn writes that prior to the confirmation hearings for Chief Justice John Roberts, the Los Angeles Times "ran a piece headlined, "Wife of Nominee Holds Strong Antiabortion Views."" According to the Times, Roberts" wife worked for Feminists for Life, and the paper "characterized [her] as an "extremely, extremely devout Catholic,"" McGurn writes."It"s possible, of course, that Democrats and their allies in the media and activist community no longer regard Catholics with the suspicion they did back when ... Bush"s nominees were up for consideration," according to McGurn. "More likely, the relatively soft reaction to Ms. Sotomayor"s Catholicism is because of a calculation that when it comes to hot-button issues such as abortion or gay marriage, she doesn"t really believe what her church teaches," he writes.McGurn continues that if the "indifference" to "Sotomayor"s Catholicism were truly a sign of a new respect for the "no religious test" provisions of the Constitution, that would be something to celebrate." He concludes, "But in the unlikely case that this "wise Latina" ever comes to see the legal wisdom of overturning [Roe v. Wade] and returning abortion to the democratic process, we"ll be reading a very different story" (McGurn, Wall Street Journal, 7/14).
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Low Oxygen Levels In Prostate Tumors Can Predict Recurrence: Long-Term Study

Fox Chase Cancer Center researchers have discovered that low-oxygen regions in prostate tumors can be used to predict a rise in prostate-specific antigen (PSA) levels, a marker of tumor recurrence in prostate cancer. The long-term study results were presented at the 2009 American Society of Clinical Oncology annual meeting in Orlando, FL. Aruna Turaka, M.D., radiation oncology fellow at Fox Chase and lead author on the study, explained that low oxygen, or hypoxia, in tumors is a well-known risk factor for radiation resistance in solid tumors. Between 2000 and 2002, Fox Chase research colleagues published six research papers detailing the link between tumor hypoxia, radioresistance, and the risk of increased PSA levels. But mean follow-up at the time of those studies was 19 months, she said. The current study reinforces those preliminary findings with more "mature" data and a median follow-up of 8 years. In the current study, Turaka and her colleagues used a custom-built probe to monitor the amount of oxygen that prostate tumors and non-cancerous muscle tissue were receiving. They used this probe on 57 patients with low or intermediate risk of cancer just before the patients received a form of localized radiation therapy. The researchers then tracked the patients over time, looking for a correlation between the amount of oxygen levels in the prostate tumor relative to the muscle tissue at the time of therapy and later looked at the increase in PSA levels. Eight of the 57 patients experienced an increase in PSA levels following prostate cancer treatment, defined as an increase of 2 ng/mL above the lowest PSA reading following brachytherapy. Overall, average muscle oxygenation was 12.5-times higher than that of the tumor (30 mm Hg vs 2.4 mm Hg). Using a statistical model that accounted for such risk factors as tumor grade, PSA level, and tumor size, the team determined that hypoxia was a significant independent predictor of an increase in PSA levels. In other words, even after accounting for PSA value, Gleason score, tumor size, age, and other prostate cancer risk factors, tumor hypoxia alone could predict the likelihood of increased PSA levels, and potentially tumor recurrence. "Now", Turaka said, "the goal is to apply the results to the clinic". That, she said, requires a two-pronged approach: developing noninvasive screening methods to identify hypoxic tumors, and more potent anticancer weapons to target them. "We already knew that there are hypoxic regions within cancers," she said. "The future goal is to interpolate that to relate to the expression of molecular markers [such as hypoxia-inducible factor-1-alpha] and attack those tumors with dose escalation radiation oncology strategies and targeted agents." The findings were described in a poster presentation at ASCO 2009. In addition to FCCC, the authors included researchers from the University of Pennsylvania in Philadelphia, PA, and the Henry Ford Health System, Detroit, MI. Abstract #5136: Correlation of hypoxic prostate/muscle pO2 (P/M PO2) ratio and biochemical failure in patients with localized prostate cancer: Long-term results. Diana Quattrone Fox Chase Cancer Center


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