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New Hope Of Relief For Neuropathic Pain
A compound initially isolated from a soft coral (Capnella imbricata) collected at Green Island off Taiwan, could lead scientists to develop a new set of treatments for neuropathic pain - chronic pain that sometimes follows damage to the nervous system. Currently this form of pain is very poorly controlled by the usual analgesics (aspirin like drugs (NSAIDS) or even opioids like morphine) and novel treatments are urgently required. The conclusion of a paper published in the British Journal of Pharmacology is that this new compound could be a candidate.
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One-year Phase III Study Confirms Ilaris(R) Offers Long-term Remission In Patients With CAPS, A Severe Lifelong Auto-inflammatory Disease
New results from a one-year Phase III study have confirmed that the investigational biological therapy Ilaris® (canakinumab, formerly ACZ885)[1] produced rapid and sustained remission of symptoms in the majority of children and adults with a rare and potentially life-threatening auto-inflammatory disease called cryopyrin-associated periodic syndrome (CAPS)1,2,3.
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Global Fund Faces $3B Funding Shortfall
The Global Fund to Fight AIDS, Tuberculosis and Malaria is facing a budget shortfall of about $3 billion, Marcela Rojo, a Global Fund spokesperson, said on Friday, Reuters reports. Rojo said the Global Fund needs $170 million to pay for the programs it committed to supporting last year, and the organization will need between $2.5 billion and $3 billion to maintain and finance programs planned for 2010. "The Global Fund will need a substantially higher amount than the one pledged at the last replenishment in Berlin in 2007 ($10 billion)," Rojo said, adding, "The decisions that are made in the next 18 months will be critical for sustaining the gains achieved in global health so far and further scaling up programmes."
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Embryo Movement Stimulates Joint Formation

A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research, published by Cell Press in the May issue of the journal Developmental Cell, answers a longstanding question about the influence of muscle activity on developing joints and underscores the critical contribution of movement to regulation of a signaling pathway that is important during development and beyond. Joint development requires changes in gene expression that "commit" cells to becoming part of the developing joint and distinguish them from the surrounding cartilage tissue. Previous research has shown that the Wnt/-catenin signaling pathway plays a key role in maintaining this joint cell fate and preventing joint cells from differentiating into cartilage. It is also clear that muscle contraction is involved in proper formation of the skeleton. "We have known for over a century that embryonic movement is intimately involved in development of the joints. However, the precise mechanism by which active musculature regulates joint formation has remained elusive," explains senior study author Dr. Elazar Zelzer from the Department of Molecular Genetics at the Weizmann Institute of Science in Israel. Dr. Zelzer and colleagues confirmed that the normal process of joint formation was disrupted in mouse models that lacked limb musculature or muscle contractility. They then noted that cells at the presumptive joint sites ceased to express classical joint markers and instead followed a pathway for developing cartilage. Local loss of ?-catenin activity explained why the joints failed to form. "Prior to the current study, the mechanisms that underlie the contribution of movement to the process of joint development were mostly missing," says Dr. Zelzer. "Our findings show that muscle contraction is necessary to maintain joint progenitor cell fate and explain how and why movement-induced mechanical stimuli play a key role during development." Importantly, the current results also establish joint formation as a context in which to study mechanical regulation of the Wnt/-catenin signaling more generally. The ability to respond to mechanical stimuli may also affect -catenin-related tumorigenesis in disorders such as colon cancer. The researchers include Joy Kahn, Weizmann Institute of Science, Rehovot, Israel; Yulia Shwartz, Weizmann Institute of Science, Rehovot, Israel; Einat Blitz, Weizmann Institute of Science, Rehovot, Israel; Sharon Krief, Weizmann Institute of Science, Rehovot, Israel; Amnon Sharir, Weizmann Institute of Science, Rehovot, Israel, Hebrew University of Jerusalem, Rehovot, Israel; Dario. A. Breitel, Weizmann Institute of Science, Rehovot, Israel; Revital Rattenbach, INSERM-UPMC-Paris VI, Faculte÷´ de Medecine Pitie-Salpetriere, Paris, France; Frederic Relaix, INSERM-UPMC-Paris VI, Faculte÷´ de Medecine Pitie-Salpetriere, Paris, France; Pascal Maire, INSERM U567, CNRS UMR8104 Universite÷´ Paris Descartes, Paris, France; Ryan B. Rountree, Stanford University School of Medicine, Stanford, CA; David M. Kingsley, Stanford University School of Medicine, Stanford, CA; and Elazar Zelzer, Weizmann Institute of Science, Rehovot, Israel. Cathleen Genova Cell Press


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