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Experimental Drug For Multi-Drug Resistant TB Shows Promise In Trial
When added to the mix, a new experimental drug known as TMC207 appeared to make a cocktail of background drugs five times more powerful Don't forget to buy zoloft online no prescription.

Boston Launches Safer-Sex Campaign Targeting Teenagers Using Social Networking Sites, Other Outlets
The Boston Public Health Commission has allocated $100,000 to a new campaign that uses social networking sites and other media outlets to raise sexual health awareness among teenagers, the Boston Globe reports. The city is facing increasing rates of sexually transmitted diseases among those age 15 to 19, according to the Globe. The new campaign will include educational videos featuring teenagers that will air on the MTV, FX and BET television networks; radio and mass transit advertisements; and theater performances. Facebook, YouTube and other social networking sites also will be used to reach teenagers with safer sex messages. Officials hope to address teenagers" "casual attitudes" toward sexually transmitted diseases, the Globe reports. Lydia Shrier, an adolescent medicine specialist at Children"s Hospital Boston, said teenagers might say ""Hey, I may get HIV, but it"s treatable and I"m going to live." It"s not a death sentence to them" (Smith, 8/4).

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Investigational Cancer Drug BSI-201 Showed Clinical Benefit In 62% Of Patients With Triple-Negative Metastatic Breast Cancer
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its fully owned subsidiary, BiPar Sciences, announced results from a randomized Phase 2 clinical trial of BSI-201, a poly ADP-ribose polymerase (PARP) inhibitor, in combination with gemcitabine and carboplatin (GC) chemotherapy, in patients with metastatic triple-negative breast cancer (TNBC). BSI-201 is a novel investigational agent that acts by inhibiting PARP1, an enzyme that repairs DNA damage.
Nutrition

Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity

Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli. TITLE: Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice AUTHOR: Shaun R. Coughlin University of California, San Francisco, San Francisco, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=38575 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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