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Women Who Quit Smoking Early In Pregnancy Reduce Risks Of Preterm Birth, Stunted Fetal Growth
Pregnant women who quit smoking during the first trimester and women who never smoked during pregnancy have a similar risk of delivering preterm or very small infants, according to a study published in the journal Obstetrics and Gynecology, Reuters reports. Premature delivery and stunted infant growth are the most well-documented side effects of smoking during pregnancy, and the risks increase for older women, according to study author Laura Polakowski of the Centers for Disease Control and Prevention and colleagues. For the study, the researchers analyzed 915,441 birth certificates for infants born in 2005 in 11 states that include information on whether the woman smoked during pregnancy.The study found that 10% of women who smoked for the entire pregnancy gave birth to "preterm but not too small for gestational age" infants, compared with 8% of women who quit during the first trimester. Fifteen percent of women who smoked the entire pregnancy gave birth to full-term infants who were small for their gestational age, while 2% gave birth to premature infants who were small for gestational age. Among women who quit smoking during the first trimester, these outcomes occurred 9% and 1% of the time, respectively.After adjusting for the women"s age, previous preterm births and other factors, the researchers found that women who quit smoking in the first trimester reduced their risk of giving birth to a preterm, normal-size infant by 31%. The risk of delivering a full-term, unusually small infant was cut by 55% and the risk for delivering a preterm, unusually small infant was reduced by 53%. The risks were also reduced for women who quit smoking during their second trimester, although less significantly. The researchers found that the risk reduction was particularly high for older women -- especially those older than age 40 -- who quit smoking during the first trimester. According to the study, the results indicate that the risk of delivering a preterm or small-for-gestational-age infant for pregnant women who quit smoking during the first trimester is "comparable to those who never smoke during pregnancy" (Reuters, 7/21).

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Yale Team Identifies Key To Potential New Treatment For Allergy-Induced Asthma
In research that could lead to new asthma drugs, scientists at Yale School of Medicine, Hydra Biosciences of Cambridge, Massachusetts, and the University of California, San Francisco have discovered that a protein may be a trigger of allergy-induced asthma in mice. They also demonstrated how a drug known to reduce inflammatory and neuropathic pain may also inhibit asthma symptoms in mice. Their paper is published in the May 18-22 online Early Edition of the Proceedings of the National Academy of Sciences.
Medical Devices

Baxter To Acquire Continuous Renal Replacement Therapy Business From Edwards Lifesciences

Baxter International Inc. (NYSE:BAX) announced today a definitive agreement with Edwards Lifesciences Corporation (NYSE:EW) under which Baxter will acquire certain assets related to Edwards" hemofiltration product line, also known as Continuous Renal Replacement Therapy (CRRT). The transaction is expected to close in the third quarter of 2009, pending regulatory approvals. Under the terms of the agreement, Baxter will provide Edwards an initial cash payment of approximately $56 million upon the close of the transaction. Additionally, Baxter will receive transition services from Edwards and is expected to pay Edwards up to an additional $9 million based on revenue objectives expected to be achieved over the next two years. The impact of this transaction is immaterial to Baxter"s financial results for 2009. Hemofiltration, or CRRT, mimics the function of the kidneys 24 hours a day for patients with life-threatening kidney injuries or edema (fluid overload). CRRT provides a method of continuous yet adjustable fluid removal that can gradually remove excess fluid and waste products that build up with the acute impairment of kidney function, and is usually administered in an intensive care setting in the hospital. Baxter currently supplies solutions used in CRRT treatment globally, and is the exclusive distributor of Edwards" product in China, Latin America and the United States. Approximately 60 employees will be joining Baxter from Edwards as part of this transaction. "As an experienced leader in dialysis therapies including CRRT, this acquisition represents an extension of our existing Renal business, and demonstrates our commitment to save and sustain the lives of patients with acute kidney injuries," said Bruce McGillivray, corporate vice president and president of Baxter"s Renal business. "This acquisition expands Baxter"s existing CRRT business, which is predominantly in the United States and China, into new markets such as Europe and Australia." Baxter International Inc


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